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Cayman Chemical m-Isobutyl Ibuprofen 10mg

Supplier: Cayman Chemical 4012710 MG

An mPGES-1 inhibitor (IC50 0.2 UM) selective for mPGES-1 over COX-1 COX-2 5-LO and sEH in cell-free assays at 10 UM inhibits IL-1b-induced production of PGE2 in A549 cells and LPS-induced IL-6 and PGE2 production in J774A.1 macrophages at 10 and 1 UM respectively inhibits the formation of 5-LO products including LTB4 and 5-H(p)ETE induced by A23187 alone or with arachidonic acid and A23187 (IC50s 4.9 and 5.2 UM respectively) prevents leukocyte infiltration into the peritoneal fluid in a mouse model of zymosan-induced peritonitis at 10 mg/kg
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