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Medchemexpress LLC m-PEG5-azide | 1202681-04-6 | 100 MG
Supplier: Medchemexpress LLC HY130168100MG
m-PEG5-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups, and also strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves contain two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets the desired protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Useful in PROTAC synthesis
- Supports selective protein degradation via ubiquitin-proteasome system
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