The 145-2C11 monoclonal antibody targets mouse CD3, a 20 kDa transmembrane cell-surface protein of the immunoglobulin superfamily, expressed on T lymphocytes, NK-T cells, and developing thymocytes. It plays a role in TCR signaling, T lymphocyte activation, and antigen recognition, inducing activation, proliferation, and apoptosis by binding and stimulating the TCR.
- Isotype: Armenian Hamster IgG1
- Recommended isotype control: Polyclonal Armenian hamster IgG
- Recommended dilution buffer: pH 7.0 Dilution Buffer
- Conjugation: Unconjugated (conjugation services available)
- Immunogen: Mouse BM10-37 cytotoxic T cells
- Reported applications: In vivo T cell depletion, in vitro T cell stimulation/activation, immunofluorescence, flow cytometry, western blot
- Formulation: PBS, pH 7.0 (contains no stabilizers or preservatives)
- Endotoxin level: 1 EU/mg
- Purity: 95%
- Sterility: 0.2 m filtration
- Production: Pu