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Bio X Cell InVivoMAb Antibody, anti-mouse NKG2A/C/E, Clone 20D5, Rat IgG2a, Unconjugated, 100 MG
Supplier: Bio X Cell BE0321R100MG
The 20D5 monoclonal antibody targets mouse NKG2A, NKG2C, and NKG2E receptors, which form heterodimers with CD94. These complexes are primarily found on NK, NKT, and activated CD8+ T cells, recognizing Qa-1. NKG2A transmits inhibitory signals, while NKG2C and NKG2E transmit stimulatory signals. Blocking NKG2A signaling enhances anti-tumor immunity in murine models by boosting T and NK cell activity, making NKG2A a potential target for immune checkpoint therapy.
- Targets mouse NKG2A, NKG2C, and NKG2E
- Clone 20D5
- Isotype: Rat IgG2a,
- Unconjugated
- Formulated in PBS, pH 7.0 (no stabilizers or preservatives)
- Endotoxin level: 1 EU/mg
- Purity: 95%
- Sterilized by 0.2 m filtration
- Animal-free production
- Purified via Protein G
- Store at 4C, do not freeze
- Reported applications include in vivo and in vitro NKG2A blockade, immunohistochemistry (frozen), and flow cytometry
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