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Bio X Cell InVivoMAb, anti-mouse/human PrP, Mouse IgG2a, Unconjugated, 50 MG
Supplier: Bio X Cell BE0350R050MG
The TW1 monoclonal antibody targets mouse and human prion protein (PrP), known as PRNP, reacting with specific mouse PrP AA sequences. PrP is highly expressed in nervous systems and is implicated in prion neurodegenerative disorders. This antibody binds both normal PrPc and abnormal PrPSc, blocking PrP-tau protein interaction, and has shown to alleviate tau-related pathology in Alzheimer's disease mouse models.
- Isotype: Mouse IgG2a.
- Unconjugated (conjugation services available).
- Immunogen: Non-denatured PK-resistant PrPSc fragment.
- Applications: In vivo PrP blocking, Western blot.
- Formulation: PBS, pH 7.0, no stabilizers or preservatives.
- Endotoxin: 1EU/mg.
- Purity: 95%.
- Sterility: 0.2 m filtered.
- Production: Animal-free cell culture supernatant purification.
- Purification: Protein G.
- Storage: 4C, do not freeze.
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