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Medchemexpress LLC MAC-545496 | 838810-96-1 | 98.0% | 10 MM * 1 ML
SDP

Supplier:  Medchemexpress LLC HY13061310MM/1ML

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MAC-545496 is a potent nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), demonstrating strong binding affinity (Kd ≤ 0.1 nM). It acts as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant Staphylococcus aureus (MRSA) strains, and is intended for research use only.

  • Potently synergizes with Cefuroxime and Oxacillin against S. aureus clinical isolates.
  • Inhibits mprF expression in a concentration-dependent manner (IC50 of 0.0376 μg/mL).
  • Inhibits citrate-induced biofilm formation in wild-type strains.
  • Effective as monotherapy for MRSA-infected Galleria mellonella larvae, increasing survival.

Catalog No. 50-003-41072


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