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Medchemexpress LLC MAC-545496 | 838810-96-1 | 98.0% | 100 MG
Supplier: Medchemexpress LLC HY130613100MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), exhibiting strong binding affinity (Kd ≤ 0.1 nM). This antivirulence agent reverses β-lactam resistance in Methicillin-resistant strains (MRSA) and is intended for research use only.
- Nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR)
- Exhibits strong binding affinity to full-length GraR protein (Kd ≤ 0.1 nM)
- Reverses β-lactam resistance in MRSA strains
- Synergizes with Cefuroxime and Oxacillin against MRSA
- Inhibits mprF expression and citrate-induced biofilm formation
- Effective monotherapy for MRSA-infected Galleria mellonella larvae in vivo
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