Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
LifeSensors Tandem Ubiquitin Binding Entities (TUBE2) Magnetic 1mL
Supplier: LifeSensors UM0402M1000
Based on protein domains known to possess an affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitylated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain. In addition, TUBEs protect polyubiquitinated proteins from deubiquitination and proteasomal degradation, for detection at relatively low abundance. These properties effectively allow TUBEs to “capture” protein in a polyubiqutinated state. TUBEs are used to isolate, enrich, and identify ubiquitinated proteins from cell and tissue extracts. Magnetic beads coupled to TUBE 2 allow for efficient recovery of polyubiquitinated proteins in a single step without centrifuge. Magnetic TUBEs allow more complete removal of the unbound supernatant, with lower background. Polyubiquitinated proteins can be separated from TUBEs for proteomics or identification by Western blotting.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?