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Medchemexpress LLC MAIT-203 (acetate) | 99.1% | 2577.90 | 25 MG
Supplier: Medchemexpress LLC 25MGHYP2269A
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic that potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. It binds APC-ARM with a Ki value of 0.015 μM and a Kd value of 0.036 μΜ. This compound significantly represses the migration and invasion of colorectal cancer cells.
- Potently inhibits APC-Asef interaction
- Binds APC-ARM with a Ki value of 0.015 μM and a Kd value of 0.036 μΜ
- Significantly represses migration and invasion of colorectal cancer cells
- Reduces Asef-APC interaction in HEK293T cells
- Attenuates SW480 and HCT116 cell migration
- Decreases the active form of CDC42
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