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Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | 99.7% | 311.33 | 50 MG
Supplier: Medchemexpress LLC HY14003750MG
Mal-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs are composed of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase, while the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules possessing Azide groups
- Facilitates protein degradation through the ubiquitin-proteasome system
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