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Cayman Chemical MalabarIcon B 10mg
SDP

Supplier:  Cayman Chemical 2991110 MG

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A diarylnonanoid with diverse biological activities; an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively); active against S. aureus, B. subtilis, and S. durans (MIC = 1 UG/ml for all) and three strains of C. albicans (MICs = 4-16 UG/ml); cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous cells; increases the levels of ROS and induces apoptosis in A549 cells; reduces TBARS formation by 28.2% in rat liver mitochondria at 2 UG/ml; reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer at 10, 15, and 20 mg/kg

Catalog No. 50-298-9722


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