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Medchemexpress LLC Malotilate | 59937-28-9 | 99.47% | C12H16O4S2 | 25 MG
Supplier: Medchemexpress LLC 25MGHYA0060
Malotilate is an orally active hepatotropic and anti-fibrotic agent that selectively inhibits 5-lipoxygenase (5-LOX) with an IC50 of 4.7 μM. It prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing transferrin retention in hepatocytes.
- Selectively inhibits 5-lipoxygenase (5-LOX)
- Prevents hepatocytic injury in alcohol-pyrazole hepatitis
- Decreases hepatic acetaldehyde levels
- Prevents retention of transferrin in hepatocytes
- Reduces collagen synthesis and cell migration activity of fibroblasts in vitro
- Prevents acute experimental liver injury induced by various hepatotoxic compounds
- Normalizes reduced serum cholesterol levels in rats with carbon tetrachloride-induced liver damage
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