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Abnova™ MALT1 Split CISH Probe
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For Use With (Application):
CISH-Ce
Description
The probe is intended to be used in combination with the CISH Implementation Kit 2, which provides necessary reagents for specimen pretreatment and post-hybridization processing.
Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (proximal to the MALT1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the MALT1 breakpoint region).
Normal situation: In interphases of normal cells or cells without a translocation involving the MALT1 gene region, two red/green fusion signals appear.
Aberrant situation: One MALT1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements.
Unexpected signal patterns should be further investigated.
Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (proximal to the MALT1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the MALT1 breakpoint region).
Normal situation: In interphases of normal cells or cells without a translocation involving the MALT1 gene region, two red/green fusion signals appear.
Aberrant situation: One MALT1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements.
Unexpected signal patterns should be further investigated.
Specifications
Specifications
Content And Storage | The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18 to 25°C) and mix briefly before use. |
For Use With (Application) | CISH-Ce |
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