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Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
SDP

Supplier:  Medchemexpress LLC HYP1441A500UG

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Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.

  • Selective ASIC1a inhibitor
  • Binds to closed/inactive channels
  • Increases latency of withdrawal response in mouse tail-flick and paw-flick tests

Catalog No. 50-004-24740


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