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Medchemexpress LLC MANS peptide TFA | 99.9% | 2498.83 (free acid) | 1 MG
Supplier: Medchemexpress LLC HYP10218A1MG
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). It is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.
- Inhibits migration and invasion of lung cancer cells (CL1-0/F3, CL1-5, PC9, A549) without causing toxicity to normal cells.
- Inhibits MARCKS phosphorylation and PI3K, AKT phosphorylation, leading to downstream changes in Slug and E-cadherin expression levels.
- Prevents the loss of cell-cell adhesion and alters epithelial-mesenchymal transition (EMT) characteristics of cancer cells, thereby decreasing tumor metastasis.
- Inhibits tumor metastasis without affecting tumorigenesis in PC9 xenograft NOD/SCID mice model.
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