Invitrogen™ Human MAP2K2 (MEK2), His Tag Recombinant Protein

Catalog No.	Quantity
PV3615	10 μg
PV4005	1 mg

Catalog No. PV3615 Supplier Invitrogen™ Supplier No. PV3615

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that is known to play a critical role in mitogen growth factor signal transduction. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

Specifications

• Accession Number: P36507
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 150mM NaCl, 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100, 2mM DTT and no preservative; pH 7.5
• Gene ID (Entrez): 5605
• Molecular Weight (g/mol): 49.5 kDa
• Name: Human MAP2K2 (MEK2), His Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: AA589381; CFC4; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; ERK kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K1; MAP2K2; MAPK; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MAPKK2; MEK 1; MEK 2; MEK-1; Mek2; MEK-2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MK2; MKK1; Mkk2; OTTHUMP00000165827; PRKMK1; PRKMK2; protein kinase, mitogen activated, kinase 2, p45
• Common Name: MEK2
• Gene Symbol: MAP2K2
• Kinase Family: STE7 Kinase Family
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical binding/kinetic, Biochemical phospho-specific activity (no antibody)
• Kinase Group: Ser⁄Thr Kinases: STE Group
• Shipping Condition: Dry Ice
• System Compatibility: Z'-LYTE™, Omnia™ Bulk Substrate
• Target Entry: MAP2K2
• Target Gene: mitogen-activated protein kinase kinase 2
• Expression System: Baculovirus
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Full Length
• Form: Liquid
• Protein Subtype: Serine/Threonine Kinases
• Research Category: Signal Transduction

Safety and Handling

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