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Medchemexpress LLC MAT2A inhibitor 2 | 13299-99-5 | 99.7% | 365.85 | 100 MG
SDP

Catalog No. 5000436350
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MAT2A inhibitor 2 is an orally active inhibitor of methionine adenosine transferase 2A (MAT2A). It has been utilized in osteoporosis studies.

  • Specifically inhibits MAT2A.
  • Demonstrates oral activity.
  • Can be used in osteoporosis research.
  • Inhibits ROS levels and activation of NF-κB and MAPK pathways in osteoclasts in vitro.
  • Increases protein levels of Nrf2, HO1, and NQO1, and decreases phosphorylation levels of p65, IκBα, p-p38, p-JNK, and p-ERK in BMMs in vitro.
  • Inhibits mRNA expression levels of NFATc1, c-FOS, TRAP, CTSK, and MMP9 in BMMs in vitro.
  • Prevents bone loss induced by ovariectomy in mice in vivo.
  • Attenuates trabecular thickness and osteoclast surface/bone surface ratio in an OVX-induced osteoporosis model.

Catalog No. 50-004-36350 Supplier Medchemexpress LLC Supplier No. HY112569100MG
May include imposed supplier surcharges.
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MAT2A inhibitor 2 is an orally active inhibitor of methionine adenosine transferase 2A (MAT2A). It has been utilized in osteoporosis studies.

  • Specifically inhibits MAT2A.
  • Demonstrates oral activity.
  • Can be used in osteoporosis research.
  • Inhibits ROS levels and activation of NF-κB and MAPK pathways in osteoclasts in vitro.
  • Increases protein levels of Nrf2, HO1, and NQO1, and decreases phosphorylation levels of p65, IκBα, p-p38, p-JNK, and p-ERK in BMMs in vitro.
  • Inhibits mRNA expression levels of NFATc1, c-FOS, TRAP, CTSK, and MMP9 in BMMs in vitro.
  • Prevents bone loss induced by ovariectomy in mice in vivo.
  • Attenuates trabecular thickness and osteoclast surface/bone surface ratio in an OVX-induced osteoporosis model.

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