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Medchemexpress LLC Maurocalcine TFA | 269745-22-4 | 95.09% | 3858.55 (free base) | 1 MG
Supplier: Medchemexpress LLC HYP5114A1MG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2, and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound can be applied to in vivo cell tracking or other cell imaging techniques. Maurocalcine (100 nM, 24 h) increases the sensitivity of RyR2 to activating [Ca2+]i and decreases its sensitivity to inhibiting [Ca2+]i. Maurocalcine (5 μM, 4 h/24 h) shows no significant cell toxicity for HEK293.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3.
- Possesses cellular permeability.
- Induces [3H]ryanodine binding on RyR1.
- Exhibits affinity for RyR2.
- Can be used for in vivo cell tracking or cell imaging techniques.
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