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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 100 MG
Supplier: Medchemexpress LLC HY50101C100MG
Mavorixafor hydrochloride (AMD-070) is a potent, selective, and orally available CXCR4 antagonist with an IC50 value of 13 nM against CXCR4 125I-SDF binding. It also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively. This compound can be used for the study of WHIM syndrome.
- Potent and selective CXCR4 antagonist.
- Orally available.
- Inhibits replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
- Used for the study of WHIM syndrome.
- Shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
- Significantly suppresses anchorage-dependent growth of B88-SDF-1 cells.
- Impairs motility and inhibits migration and Matrigel invasion of B88-SDF-1 cells.
- Inhibits lung metastasis of B88 SDF 1 cells in nude mice.
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