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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 25 MG
Supplier: Medchemexpress LLC 25MGHY50101C
Mavorixafor hydrochloride is a potent, selective, and orally available CXCR4 antagonist. It exhibits an IC50 value of 13 nM against CXCR4 125I-SDF binding. This compound also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively, making it suitable for WHIM syndrome research. It demonstrates no effect on other chemokine receptors such as CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2.
- Potent and selective CXCR4 antagonist
- Orally available for ease of administration
- Inhibits T-tropic HIV-1 replication
- Useful for WHIM syndrome studies
- Suppresses anchorage-dependent cell growth
- Impairs cell motility and inhibits migration
- Prevents Matrigel invasion and lung metastasis in in vivo models
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