Medchemexpress LLC MBQ-167 | 2097938-73-1 | 99.9% | 338.41 | 1 ML

Supplier:  Medchemexpress LLC HY11284210MM/1ML

MBQ-167 is a dual Rac/Cdc42 inhibitor. It has IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells. It is for research use only and not sold to patients.

• Induces loss of polarity in metastatic breast cancer cells at concentrations ≥100 nM.
• Treatment with 500 nM for 24 hours results in ~95% cell rounding and detachment in MDA-MB-231 cells.
• Active in various mesenchymal cancer cell types including breast, pancreatic, ovarian, gastric, and neuroblastoma cells.
• Reduces Rac activation in MDA-MB-231 cells.
• In vivo, significantly reduces tumor growth in mice (~80% reduction at 1.0 mg/kg BW and ~95% reduction at 10 mg/kg BW).
• 10X more effective than EHop-016 in reducing tumor growth in mice.

Catalog No. 50-004-37895