Medchemexpress LLC Mbq-167 | 2097938-73-1 | 99.9% | 338.41 | 100 MG

Supplier:  Medchemexpress LLC HY112842100MG

MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells. It is for research use only.

• Dual Rac/Cdc42 inhibitor.
• Available in solid and solution forms.
• Significantly reduces migration of liver specific Dnmt3a-/- hematopoietic cells at 200 nM (20 h).
• Induces a loss of polarity in metastatic breast cancer cells at concentrations ≥100 nM.
• Causes ~95% cell rounding and detachment in metastatic MDA-MB-231 cells at 500 nM for 24 h.
• Inhibits Rac activity in attached and detached cancer cells.
• Induces phenotype in various mesenchymal cancer cell types.
• Demonstrates a statistically significant reduction in tumor growth in treated mice, with an ~80% reduction at 1.0 mg/kg BW and ~95% reduction at 10 mg/kg BW.
• 10 times more effective than EHop-016 in reducing tumor growth in mice.

Catalog No. 50-004-37778