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CPC Scientific MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(DNP)-OH (trifluoroacetate salt) 0.5MG
SDP

Supplier:  CPC Scientific AMYD111A

Encompass

Very sensitive and internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10^7 M-1s-1 and 1.7 x 10^6 M-1s-1 for the hydrolysis by neprilysin. For MMP-2, MMP-9 the kcat/Km values are in the range of 10^4 M-1s-1 whereas for MMP-1 there was no hydrolysis observed. This peptide was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km = 218000 M-1s-1 and very slowly by gelatinase B (MMP-9) (kcat/Km=10100 M-1s-1). There was no hydrolysis by MMP-1 and MMP-2 observed.ONE-LETTER SEQUENCE: Mca-RPPGFSAF-Lys(Dnp)MOLECULAR FORMULA: C66H81N15O19MOLECULAR WEIGHT:1388.46STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [323577-36-2], SYNONYMS: Mca-(Ala,Lys(Dnp))-BradykininRESEARCH AREA: Alzheimer's Dise

Catalog No. 50-210-8738


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