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Enzo Life Sciences Mca-APK(Dnp) (1 mg)
SDP

Supplier:  Enzo Life Sciences BMLP1630001

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ACE substrate. Fluorogenic substrate for angiotensin converting enzyme-2 (ACE2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp), this substrate is not cleaved by caspases. Mca fluorescence is quenched by the Dnp group until cleavage (at Pro-Lys) separates them. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have also been used: 320-340/400-420. This highly quenched (99.6%) substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic Mca control peptide (BML-P127). Alternative Name: ACE2 substrate (fluorogenic). Formula: C32H37N6O12. MW: 697.7. Purity: ≥95% (HPLC). Sequence Mca-Ala-Pro-Lys(Dnp)-OH  [Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl]. Appearance: Yellow powder. Solubility: Soluble in DMSO or 10% Ammonium Hydroxide (2 mg/ml). Long Term Storage: -20°C. Use/Stability: Stock solutions in DMSO stable at -20°C. Handling: Protect from light and moisture.

Catalog No. NC1366248


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