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Cayman Chemical McaRPPGFSAFK DnpOHtrIflu 10mg
SDP

Supplier:  Cayman Chemical 3688710 MG

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An inhibitor of Notch signaling binds to the BTD domain of RBPJ and inhibits the assembly of the RBPJ-NICD transcription complex inhibits ligand-induced Notch signaling in HeLa cells expressing mouse Notch1 -2 -3 or -4 (IC50s 1.5 0.9 1.1 and 2.9 UM respectively) reduces expression of the Notch target genes HES1 MYC and DTX1 in RPMI-8402 T-ALL cells reduces tumor volume and increases survival in an HCC-1187 mouse xenograft model at 25 mg/kg

Catalog No. 50-291-5283


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