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Medchemexpress LLC MCB-22-174 | 3058199-58-6 | 99.8% | 429.37 | 5 MG
Supplier: Medchemexpress LLC HY165607S5MG
MCB-22-174 is a deuterated Piezo1 agonist with an EC50 value of 6.28 μM. It activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. It decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. This compound can improve bone quality in hind-limb unloading (HU) model rats and can be used for the study of disuse osteoporosis (OP).
- Deuterated Piezo1 agonist
- Activates the CaMKII/ERK signaling pathway
- Initiates Ca2+ influx in rMSCs
- Decreases expression of chondrogenesis markers (Comp, Acan) in MSCs
- Decreases expression of adipogenesis markers (Lpl, Fabp4) in MSCs
- Effectively improves bone quality in hind-limb unloading (HU) model rats
- Can be used for the study of disuse osteoporosis (OP)
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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