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Apexbio Technology LLC MCB-613 1162656-22-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A87125.1
MCB-613 (CAS 1162656-22-5) is a small-molecule stimulator of steroid receptor coactivators (SRCs) transcriptional regulators that modulate gene expression downstream of nuclear receptors and signaling pathways It potently activates all three SRC family proteins significantly enhancing their interactions with additional coactivators such as CBP and CARM1 thus amplifying downstream transcriptional activity In cancer models (prostate PC-3 breast MCF-7 liver HepG2 Lung H1299) MCB-613 demonstrates cytotoxicity through selective induction of endoplasmic reticulum stress coupled with reactive oxygen species (ROS) The compound provides a probe for investigating SRC biology and cancer cell dependency on SRC activation
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