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Medchemexpress LLC MCC950 sodium | 256373-96-3 | 99.8% | 200 MG
Supplier: Medchemexpress LLC HY12815A200MG
MCC950 sodium is a potent and selective NLRP3 inhibitor with IC50s of 7.5 nM in BMDMs and 8.1 nM in HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations and specifically inhibits NLRP3 but not AIM2, NLRC4, or NLRP1 activation.
- Potent and selective NLRP3 inhibitor
- Inhibits IL-1β but not TNF-α secretion
- Blocks canonical and non-canonical NLRP3 activation
- Specifically inhibits NLRP3 (not AIM2, NLRC4, or NLRP1)
- Reduces Interleukin-1β (IL-1β) production
- Attenuates severity of experimental autoimmune encephalomyelitis (EAE)
- Off-white to yellow solid appearance
- Purity of 99.8%
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