Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 10 MG

Supplier:  Medchemexpress LLC HY12859810MG

MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. This compound can be utilized for the study of acute lung injury (ALI).

• Exerts anti-inflammatory activity by inhibiting NF-κB in RAW264.7 macrophages.
• Directly binds to the MD2-TLR4 complex and disrupts MD2-TLR4 activation.
• Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages.
• Significantly inhibits macrophage infiltration and ameliorates histopathological changes in lung tissues.
• Effectively reduces airspace inflammation and amends pulmonary lobule tissue structure.
• Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels.
• Reduces mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues.

Catalog No. 50-003-40845