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Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 100 MG
SDP

Supplier:  Medchemexpress LLC HY128598100MG

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MD2-TLR4-IN-1 is an antagonist of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages. This product is suitable for research related to acute lung injury (ALI).

  • Inhibits NF-κB in RAW264.7 macrophages
  • Directly binds to the MD2-TLR4 complex and disrupts its activation
  • Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages
  • Significantly inhibits dimerization of the MD2-TLR4 complex in LPS-activated mouse primary macrophages (MPMs)
  • Reduces airspace inflammation and ameliorates histopathological changes in lung tissues of LPS-challenged mice
  • Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels
  • Lowers mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues

Catalog No. 50-003-38285


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