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Apexbio Technology LLC MDL 28170 88191-84-8 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A44125.1

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MDL 28170 (CAS 88191-84-8) is a selective inhibitor of calpain and cathepsin B with Ki values of approximately 10 nM and 25 nM respectively It acts by directly blocking the catalytic site of these cysteine proteases without inhibiting serine proteases MDL 28170 readily penetrates the blood-brain barrier inhibiting protease activity in brain tissue and mitigating ischemia-induced neurological damage in animal models The compound reduces muscle fiber sensitivity to calcium influx post-ischemia and limits myocardial injury caused by calcium overload It also exhibits antiparasitic activity in vitro significantly lowering Trypanosoma cruzi survival in infected macrophages MDL 28170 is used in biomedical research to study protease-related pathology ischemic injury and parasite-host interactions

Catalog No. 50-000-62457


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