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Medchemexpress LLC MDL-29951 | 130798-51-5 | 99.2% | 302.11 | 5 MG
SDP

Catalog No. 502030711
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MDL-29951 is a novel glycine antagonist of NMDA receptor activation, exhibiting a Ki of 0.14 μM for [3H]glycine binding both in vitro and in vivo. It is intended for research use only.

  • Approximately 2000-fold selective for the glycine binding site over glutamate recognition sites.
  • Inhibits human F16Bpase (IC50=2.5 μM), porcine kidney (IC50=1.0 μM), and rabbit liver (IC50=0.21 μM) isoforms of the enzyme.
  • Promotes Ca2+ signaling responses and inhibits cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells.
  • Exhibits GPCR-mediated signaling activities, including G protein-dependent activation of ERK1/2 and recruitment of β-arrestin.

Catalog No. 50-203-0711 Supplier Medchemexpress LLC Supplier No. HY163125MG
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MDL-29951 is a novel glycine antagonist of NMDA receptor activation, exhibiting a Ki of 0.14 μM for [3H]glycine binding both in vitro and in vivo. It is intended for research use only.

  • Approximately 2000-fold selective for the glycine binding site over glutamate recognition sites.
  • Inhibits human F16Bpase (IC50=2.5 μM), porcine kidney (IC50=1.0 μM), and rabbit liver (IC50=0.21 μM) isoforms of the enzyme.
  • Promotes Ca2+ signaling responses and inhibits cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells.
  • Exhibits GPCR-mediated signaling activities, including G protein-dependent activation of ERK1/2 and recruitment of β-arrestin.

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