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Apexbio Technology LLC MDV3100 (Enzalutamide) 915087-33-1 25mg
Supplier: Apexbio Technology LLC A300325
MDV3100 (Enzalutamide) is a nonsteroidal androgen receptor (AR) antagonist developed as a second-generation inhibitor for prostate cancer research Structurally distinct from earlier AR antagonists such as bicalutamide it exhibits high affinity binding to the androgen receptor ligand-binding domain thereby blocking AR activation steps Specifically it inhibits androgen binding nuclear translocation of the AR and AR-DNA interaction Preclinical studies in prostate cancer cell lines with AR gene amplification including VCaP have indicated that MDV3100 can induce apoptosis MDV3100 serves as a research tool for investigating androgen receptor-mediated pathways and cellular processes in prostate cancer models
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