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Apexbio Technology LLC MDV3100 (Enzalutamide) 915087-33-1 25mg
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Catalog No. 5000063369
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MDV3100 (Enzalutamide) is a nonsteroidal androgen receptor (AR) antagonist developed as a second-generation inhibitor for prostate cancer research Structurally distinct from earlier AR antagonists such as bicalutamide it exhibits high affinity binding to the androgen receptor ligand-binding domain thereby blocking AR activation steps Specifically it inhibits androgen binding nuclear translocation of the AR and AR-DNA interaction Preclinical studies in prostate cancer cell lines with AR gene amplification including VCaP have indicated that MDV3100 can induce apoptosis MDV3100 serves as a research tool for investigating androgen receptor-mediated pathways and cellular processes in prostate cancer models

Catalog No. 50-000-63369 Supplier Apexbio Technology LLC Supplier No. A300325
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MDV3100 (Enzalutamide) is a nonsteroidal androgen receptor (AR) antagonist developed as a second-generation inhibitor for prostate cancer research Structurally distinct from earlier AR antagonists such as bicalutamide it exhibits high affinity binding to the androgen receptor ligand-binding domain thereby blocking AR activation steps Specifically it inhibits androgen binding nuclear translocation of the AR and AR-DNA interaction Preclinical studies in prostate cancer cell lines with AR gene amplification including VCaP have indicated that MDV3100 can induce apoptosis MDV3100 serves as a research tool for investigating androgen receptor-mediated pathways and cellular processes in prostate cancer models

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