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Apexbio Technology LLC Mebendazole 31431-39-7 25g
Supplier: Apexbio Technology LLC C408725000
Mebendazole (CAS 31431-39-7) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule polymerization thereby impairing cellular structural integrity in parasites and tumor cells Mebendazole exerts its biological activity primarily by binding to tubulin and inhibiting microtubule assembly In cell-based studies mebendazole demonstrates activity against Giardia isolates with a 24-h IC50 of 0 19 M and induces apoptosis in melanoma cell lines (average IC50 0 32 mol/L) associated with Bcl-2 phosphorylation and mitochondrial pathway activation In lung cancer cellular studies mebendazole induces G2-M arrest prior to apoptosis in vivo it suppresses growth of lung cancer xenografts in mice Based on these pharmacological properties mebendazole holds research potential in parasitic infections melanoma and lung cancer
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