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Apexbio Technology LLC Mecamylamine hydrochloride 826-39-1 10mg
Supplier: Apexbio Technology LLC B720510
Mecamylamine hydrochloride (CAS 826-39-1) is an orally active non-selective non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) capable of crossing the blood-brain barrier It inhibits the amplitude of induced end plate currents at a holding potential of 70 mV with an IC50 of 7 8 M and a Hill coefficient of 1 2 indicating moderate cooperativity In behavioral studies intraperitoneal administration of mecamylamine (0 5 1 mg/kg) in C57BL/6J mice produces antidepressant-like effects in both the tail suspension and forced swim tests effects which are dependent on the 2 and 7 nAChR subunits This compound is widely utilized in neuropsychiatric and neuropharmacological research
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