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Medchemexpress LLC Mecamylamine hydrochloride | 826-39-1 | 98.0% | 25 MG
SDP

Catalog No. 5000414102
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Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist and ganglionic blocker that can cross the blood-brain barrier. It is used in the research of neuropsychiatric disorders, hypertension, and antidepressant areas. It increases the firing frequency of identified 5-HT DRN neurons and blocks histamine receptor.

  • Increases glutamatergic and decreases GABAergic input of 5-HT DRN neurons
  • Blocks histamine receptor and histamine-induced contractions in helically cut strips of rabbit aorta
  • Dose-dependently attenuates endothelial tube formation in HDMVECs
  • Reduced nicotine-facilitated increase in ERK1/2 in SCG neurons
  • Inhibits Choroidal neovascularization (CNV) in CNV mice model
  • Has antidepressant-like effects in both the TST and FST in C57BL/6J mice

Catalog No. 50-004-14102 Supplier Medchemexpress LLC Supplier No. 25MGHYB1395
May include imposed supplier surcharges.
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Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist and ganglionic blocker that can cross the blood-brain barrier. It is used in the research of neuropsychiatric disorders, hypertension, and antidepressant areas. It increases the firing frequency of identified 5-HT DRN neurons and blocks histamine receptor.

  • Increases glutamatergic and decreases GABAergic input of 5-HT DRN neurons
  • Blocks histamine receptor and histamine-induced contractions in helically cut strips of rabbit aorta
  • Dose-dependently attenuates endothelial tube formation in HDMVECs
  • Reduced nicotine-facilitated increase in ERK1/2 in SCG neurons
  • Inhibits Choroidal neovascularization (CNV) in CNV mice model
  • Has antidepressant-like effects in both the TST and FST in C57BL/6J mice

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