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Medchemexpress LLC MedChemExpress ITK PROTAC Degrader, ITK Target, 1022.20 MW, 98.31% Purity
Supplier: Medchemexpress LLC HY18520610MG
BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. It blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. This compound enhances the sensitivity of T-cell lymphoma cells to chemotherapy and is applicable to research related to T-cell lymphoma.
- Targets and degrades ITK in T-cell lymphoma cell lines.
- Blocks the activation of the NF-κB/GATA-3 signaling pathway.
- Inhibits PLCγ1 phosphorylation.
- Reduces the proliferative capacity of T-cell lymphoma cells.
- Enhances the sensitivity of T-cell lymphoma cells to chemotherapy.
- Decreases tumor volume in mouse models.
- Reverses chemotherapy resistance in mouse models.
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