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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A35935.1

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Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials

Catalog No. 50-000-63258


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