Apexbio Technology LLC MEK162 (ARRY-162, ARRY-438162) 606143-89-9 50mg

Supplier:  Apexbio Technology LLC A194750

MEK162 (ARRY-162 ARRY-438162 CAS 606143-89-9) is a selective inhibitor of MEK1 and MEK2 kinases exhibiting an IC50 of approximately 12 nM By targeting the MAPK/ERK signaling pathway MEK162 inhibits ERK1/2 phosphorylation reduces clonal survival and induces apoptosis in melanoma cell models including those harboring N-RAS GNAQ or GNA11 mutations Studies also indicate that combining MEK162 with PKC inhibitors leads to sustained suppression of MAPK signaling and enhanced pro-apoptotic effects in uveal melanoma cells Early-phase clinical research has reported transient typically mild retinopathy associated with MEK162 treatment This compound is widely utilized in studies of targeted melanoma therapies

Catalog No. 50-000-97312