Medchemexpress LLC Melagatran | 159776-70-2 | 99.3% | 1 MG

Supplier:  Medchemexpress LLC HY1290561MG

Melagatran is a reversible, selective, and orally active direct inhibitor of thrombin, with a Ki of 2 nM. It functions by binding directly to the active site of thrombin, inhibiting the conversion of fibrinogen to fibrin. This compound also reduces the DNA binding activity of NF-κB and AP-1, making it relevant for research in cardiovascular diseases and ischemic brain damage. It has been shown to alleviate ischemic brain damage and decrease the size of advanced atherosclerotic lesions.

• Targets thrombin with a Ki of 2 nM.
• Alleviates endotoxin-induced systemic hemodynamic disorders.
• Prevents or delays electrically induced occlusive thrombus formation.
• Demonstrates good oral bioavailability.
• Reduces ischemic brain injury in rats.
• Reduces advanced atherosclerotic lesion size and promotes plaque stability.
• Decreases DNA binding activity of NF-κB and AP-1.

Catalog No. 50-003-41139