Melphalan, 94%

Description

Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity. | CAS: 148-82-3 | C₁₃H₁₈Cl₂N₂O₂ | 305.2 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
• Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells

Applications

• Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
• In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases

Specifications

Chemical Identifiers

• CAS: 148-82-3
• Molecular Formula: C₁₃H₁₈Cl₂N₂O₂
• Molecular Weight (g/mol): 305.2
• InChI Key: SGDBTWWWUNNDEQ-LBPRGKRZSA-N
• Synonym: melphalan, alkeran, melfalan, phenylalanine mustard, l-sarcolysine, l-pam, l-sarcolysin, l-phenylalanine mustard, levofalan, p-l-sarcolysin
• PubChem CID: 460612
• ChEBI: CHEBI:28876
• IUPAC Name: (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
• SMILES: C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl

• Melting Point: 180.0°C
• Infrared Spectrum: Authentic
• Assay Percent Range: 93% min. (HPLC)
• Packaging: Glass Bottle
• Linear Formula: (ClCH₂CH₂)₂NC₆H₄CH₂CH(NH₂)COOH
• Quantity: 1 g
• Formula Weight: 305.2
• Percent Purity: 94%
• Chemical Name or Material: Melphalan

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause cancer. Suspected of damaging fertility or the unborn child.<br/
Precautionary Statement	GHS P Statement IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF ON SKIN: Wash with plenty of soap and water. Take off contaminated clothing and wash before reuse. IF IN EYES: Rinse cautio
EINECSNumber	205-726-3

SDS

RUO – Research Use Only