Sigma Aldrich Fine Chemicals Biosciences Membrane Scaffold Protein5MG

Supplier:  Sigma Aldrich Fine Chemicals Biosciences MSP035MG

Nanodisc technology is an approach to render membrane proteins soluble in aqueous SOLUTIONons in a native-like bilayer environment where the membrane proteins remain stable and active. The Nanodisc concept is derived from high density lipoprotein (HDL) particles and their primary protein component apolipoprotein. The Nanodisc is a non-covalent structure of phospholipid bilayer and membrane scaffold protein (MSP) a genetically engineered protein which mimics the function of Apolipoprotein A-1 (ApoA-1).The first MSP MSP1 was engineered with its sequence based on the sequence of A-1 but without the globular N-terminal domain of native A-1. The Membrane Scaffold Protein 1D1 (MSP1D1) variant of MSP1 deletes the first 11 amino acids in the Helix 1 portion (H1 in the accompanying figure) of the original MSP1 sequence. The MSP1D1(-) variant of MSP1D1 omits both the histidine-tag and the TEV protease-recognition sequence.

Catalog No. 50-290-4393