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Medchemexpress LLC Menin-MLL inhibitor MI-2 | 1271738-62-5 | C18H25N5S2 | 1 ML

Supplier: Medchemexpress LLC HY1522210MM/1ML
Menin-MLL inhibitor MI-2 is a competitive and selective Menin-MLL interaction inhibitor. It effectively downregulates target genes like HOXA9 and MEIS1, leading to inhibition of leukemia cell proliferation and induction of apoptosis and differentiation. This compound shows promise in the research of MLL-rearranged acute leukemias, including AML and ALL, with an IC50 of 446 nM and a Ki value of 158 nM.
- Competitive and selective Menin-MLL interaction inhibitor
- Downregulates expression of target genes (HOXA9, MEIS1)
- Inhibits proliferation of leukemia cells
- Induces apoptosis and differentiation
- Promising for research of MLL-rearranged acute leukemias
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