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Selleck Chemical LLC Merestinib
Supplier: Selleck Chemical LLC S701425MG
Merestinib (LY2801653) is a type-II ATP competitive slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM a pharmacodynamic residence time (Koff) of 0 00132 min(-1) and t1/2 of 525 min Merestinib (LY2801653) also inhibits MST1R AXL ROS1 MKNK1/2 FLT3 MERTK DDR1 and DDR2 with IC50 of 11 nM 2 nM 23 nM 7 nM 7 nM 10 nM 0 1 nM and 7 nM respectively
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