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Apexbio Technology LLC Merimepodib 198821-22-6 2mg
Supplier: Apexbio Technology LLC B11122
Merimepodib (CAS 198821-22-6) is a small-molecule inhibitor targeting inosine monophosphate dehydrogenase (IMPDH) It is designed to inhibit IMPDH thereby blocking the conversion of inosine monophosphate to xanthosine monophosphate and impacting guanine nucleotide biosynthesis Merimepodib exerts its biological activity primarily through noncompetitive inhibition of IMPDH In in vitro studies Merimepodib demonstrates antiproliferative effects suppressing lymphocyte cell growth at approximately 100 nM It also shows antiviral activity with IC50 values of 0 38 M for HBV 0 80 M for HCMV 1 0 M for EMCV and 1 14 M for RSV Based on these pharmacological properties Merimepodib holds research potential in antiviral therapy immunosuppression and transplant rejection models
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