Biocare Medical, LLC Mesothelin Antibody - Concentrate, 0.5 ml

Supplier:  Biocare Medical, LLC ACI3175B

Mesothelin is a cell surface glycoprotein that elicits T cell responses, first described as the antigenic target of the K1 monoclonal antibody, generated by using an ovarian cell line as immunogen (1,7). In normal tissues, mesothelin expression is largely restricted to mesothelial cells. However, immunoreactivity for this marker has also been reported in some epithelial cells of the trachea, tonsil, kidney, and fallopian tube (1). Mesothelin is one of the most sensitive markers for mesothelioma, and it has been reported to be expressed in all or nearly all epithelioid mesotheliomas as well as in some carcinomas, particularly those arising in the ovary (serous carcinomas) and pancreas (1-7). Epithelioid mesotheliomas and adenomatoid tumors invariably express mesothelin, and the reaction is usually strong and diffuse and occurs along the cell membrane. This is in contrast to sarcomatoid mesotheliomas, which are usually negative for this marker (6,8). Among carcinomas, most pancreatic ade

Catalog No. NC1747952