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Cayman Chemical Metacetamol 500g
SDP

Supplier:  Cayman Chemical 33404500 G

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A positive allosteric modulator of GABAB receptors enhances GABA binding with a maximal effect of 143 compared to a GABA-only control in CHO cells membranes expressing the GABAB(1b/2) receptor and enhances GABA binding to rat cortical membranes at 30 UM selective for GABA binding to heterodimeric GABAB(1b/2) over monomeric GABAB(1b) receptors potentiates the efficacy of baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat VTA in vitro (EC50 0.27 UM) also potentiates the sedative-reducing effects induced by baclofen or GHB in rats at 10-170 mg/kg suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period at 25-100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg

Catalog No. 50-294-9814


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