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Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Supplier: Medchemexpress LLC HYB0449200MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
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