Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY162713

MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors. This compound shows good tolerability in in vivo studies, without causing hyperglycemia, a common side effect of PI3K inhibitors.

• Inhibits EGFR with an IC50 of 14.7 nM, and PI3K with IC50 values ranging from 1.1 nM to 233 nM.
• Demonstrates anti-tumor effects, suppressing tumor proliferation and growth.
• Acts as a weak agonist of PPARγ with an IC50 of 2.5 μM, which helps to alleviate hyperglycemia.
• Indicates excellent tolerance in mice and the absence of hyperglycemia in vivo.

Catalog No. 50-003-95426