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Apexbio Technology LLC Methazolamide 554-57-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43645.1
Methazolamide (CAS 554-57-4) is a sulfonamide-derived inhibitor of carbonic anhydrase (CA) selectively targeting isoforms CAII and CAIV with IC50 values of 8 1 nM and 80 3 nM respectively By suppressing CA activity methazolamide reduces bicarbonate ion production thus decreasing fluid secretion and intraocular pressure consequently it has clinical use in glaucoma management Recent studies indicate this compound also exhibits insulin-sensitizing properties distinct from other CA inhibitors notably reducing hepatic glucose output suggesting potential applications in diabetes research and metabolic disorders
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